Medical Research Projects Assessment of the etiological role of emerging microorganisms in human infectious diseases

Assessment of the etiological role of emerging microorganisms in human infectious diseases. Use of phenotypic and molecular markers in their monitoring

  • Project :
    • Assessment of the etiological role of emerging microorganisms in human infectious diseases. Use of phenotypic and molecular markers in their monitoring. (INFECTIO)
  • Project Manager :
    • Prof. Dr. Petre Calistru
  • Coordinating Institution :
    • "Dr. Victor Babes" Clinical Hospital for Infectious and Tropical Diseases (SVB), Bucharest
      • SVB Coordinator: Dr. Nica Maria
  • Associated Organisations :
    • P1 - National Institution for Research and Development in Microbiology and Immunology Cantacuzino
      • Coordinator P1 : PhD. Maria Damian
    • P2 - FVB Coordinator
      • Coordinator P2 : PhD. Gh. Voiculescu
    • P3 - Carol Davila University of Medicine and Pharmacy - The Infectious and Tropical Diseases Department
      • Coordinator P3 : University Professor, senior MD, PhD. Em. Ceausu
    • P4 - CF Witing University Hospital, Bucharest
      • Coordinator P4: University Professor, senior MD, PhD. Ungureanu Florin Dan
  • The running period :
    • September 2006 - September 2008
  • Financed by :
    • Ministry of Education and Research - The National Center for Management Programs : CEEX 143 / 2006 (BIOTECH)
  • About project :
    • The human organism, in its physiochemical condition complexity, represents an ecological niche that can be colonized by lots of microorganisms, often caught from the environment. Within the healthy host, this colonization is limited by the immune system, while in the case of the host with an impaired immune system, only the antibiotics manage to maintain a control on the microbial colonization.
    • The alarming increase of the affections given by microorganisms known as non- pathogenic, both in singular patients and mostly in cases of epidemiology events with a hotbed aspect( hospital interior infections), determined by the microbiologic studies orientation to those taxonomic groups known as time- servers and commensalisms.
    • The purpose of this project is to develop molecular methods to analyze the pathogenic properties of bacterial agents involved in emergent infections.
    • Achieving a permanent research partnership between the microbiological laboratories and the clinicians from the hospitals, bring the advantage of some rapid and efficient interventions in the apparition of infections caused by emergent pathogenic germs- resulted from genetic mutations.
    • The expected results of the new strategy to combating bacterial emergence infections are :
      • achieving a correct, by clinical reason, epidemiological and laboratory study, and bacterial etiology
      • the evolution of the patient's state of health and short time recovery
      • decreasing and limitation of pathogen strains
      • decreasing in expense, number of hospitalization days by applying a new rational antimicrobial therapy
      • phenotypic and molecular studies on circular strains, and also on the resistant types involved in nosocomial infections, allow general epidemiologic studies, referring to autochthonous pathogens circulation and to the most appropriate therapeutic solutions
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